Sorry I forgot to update, the good news is its running smooth again with no knocking but Im afraid I can't comment on what was causing it to knock but the throttle response issue I think was down to the incompatible or duff iat sensor that I was using (aem). So I Resorted back to the na oem one and had it remapped again.
If I remember rightly the tps was slightly out so I reset it and had the map tweaked because I had to put a new e-manage in, that's when the knock stopped, then lately iv just removed the aem iat sensor and put the na one back in and opted for a full remap again from tuning developments which resulted in it making slightly more power from 370 to 385bhp and more importantly it drives better!